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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

8.4K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
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The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Action Potentials01:41

Action Potentials

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Overview
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Action Potential01:31

Action Potential

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Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
8.0K
Action Potential: Phases of Stimulation01:28

Action Potential: Phases of Stimulation

6.2K
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
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Related Experiment Video

Updated: Aug 1, 2025

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
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Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

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Voltage-Gated Potassium Channels Beyond the Action Potential.

Luis A Pardo1

  • 1Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences (MPI-NAT), Göttingen, Germany.

Bioelectricity
|May 1, 2023
PubMed
Summary

Bioelectricity research expanded from studying ion channels in excitable tissues to investigating the Kv10.1 potassium channel

Area of Science:

  • Biophysics
  • Molecular Biology
  • Cancer Research

Background:

  • Bioelectricity encompasses more than just neural electrical signaling.
  • Initial research focused on the biophysics of ion channels in electrically excitable tissues.

Purpose of the Study:

  • To explore the broader field of bioelectricity beyond the nervous system.
  • To investigate the pathogenic roles of the Kv10.1 potassium channel in cancer.

Main Methods:

  • Biophysical studies of ion channels.
  • Investigation of Kv10.1 channel function in cancer.

Main Results:

  • The Kv10.1 potassium channel plays a significant role in cancer pathogenesis.
  • Understanding bioelectricity requires studying diverse biological systems.
Keywords:
KCNH1Kv10.1cancerelectrophysiologyvoltage-gated potassium channels

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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies
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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies

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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

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Related Experiment Videos

Last Updated: Aug 1, 2025

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
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Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies
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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies

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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

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Conclusions:

  • The Kv10.1 potassium channel is a potential therapeutic target in cancer.
  • Bioelectricity is a critical factor in understanding both normal physiology and disease.