Reference range data base for serum chemistry and hematology values in laboratory animals

Area of Science:

• Veterinary Medicine
• Comparative Pathology
• Biomedical Research

Background:

• Accurate interpretation of animal laboratory results is crucial for research and clinical diagnostics.
• Establishing species-specific reference ranges is essential for identifying physiological and pathological variations.
• Existing reference data may be limited in scope or species coverage.

Purpose of the Study:

• To create a comprehensive reference range database for serum chemistry and hematology parameters in common laboratory animals.
• To provide statistical data including mean, standard deviation, and percentiles for key biochemical and hematological markers.
• To facilitate the routine use of these reference ranges in computerized data collection systems.

Main Methods:

• Compilation of serum chemistry and hematology data from over 3000 animals.
• Inclusion of parameters such as electrolytes, enzymes, cell counts, and indices.
• Data collection across multiple species: mouse, rat, hamster, rabbit, beagle dog, and cynomolgus monkey.

Main Results:

• A database containing mean, standard deviation, and 10th/90th percentiles for 30+ serum chemistry and hematology parameters.
• Detailed data provided for species including mouse, rat, hamster, rabbit, beagle dog, and cynomolgus monkey.
• Demonstration of the utility of these reference ranges in computerized data management.

Conclusions:

• The established reference ranges provide a valuable resource for accurate health assessment in laboratory animals.
• This database supports improved diagnostic accuracy and consistency in biomedical research.
• The findings facilitate the integration of species-specific reference data into routine veterinary diagnostics and research data analysis.