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Advanced injectable hydrogels for bone tissue regeneration.

Hassan Thoulfikar A Alamir1, Ghufran Lutfi Ismaeel1, Abduladheem Turki Jalil2

  • 1College of Pharmacy, University of Al-Ameed, Karbala, Iraq.

Biophysical Reviews
|May 1, 2023
PubMed
Summary

Biocompatible functional hydrogels offer advanced solutions for bone tissue engineering and regeneration. These injectable materials show promise for treating skeletal defects and injuries with minimally invasive approaches.

Keywords:
BiopolymersBone defectInjectable hydrogelsTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Skeletal diseases and defects pose significant challenges due to their complexity.
  • Bone tissue engineering is crucial for developing advanced treatments for bone disorders.
  • Hydrogels are emerging as promising biomaterials for skeletal repair and regeneration.

Purpose of the Study:

  • To review biocompatible functional hydrogels for cell culture and bone tissue regeneration.
  • To highlight design concepts for injectable hydrogels in bone tissue formation.
  • To discuss practical applications of hydrogels in treating bone disorders.

Main Methods:

  • Review of literature on hydrogel design and applications in bone regeneration.
  • Focus on injectable hydrogels with 3D network structures and functional capabilities.
  • Analysis of crosslinking procedures, controlled release, and bionic methodologies.

Main Results:

  • Functional hydrogels with high water content and unique 3D structures are ideal for bone tissue engineering.
  • Injectable hydrogels offer adaptable physicochemical properties for minimally invasive surgery.
  • Hydrogels can be designed for controlled drug delivery and hormone release in response to stimuli.

Conclusions:

  • Biocompatible functional hydrogels represent a promising avenue for bone tissue regeneration.
  • Injectable hydrogels provide versatile solutions for complex skeletal defects and injuries.
  • Further development of hydrogel scaffolds is essential for advancing bone defect treatments.