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Crosslinking Improve Demineralized Dentin Performance and Synergistically Promote Biomimetic Mineralization by
Lin Tang1, Lingli Zhu1, Yuhua Liu1
1Department of Prosthodontics & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, P. R. China.
Chemical crosslinking, particularly with procyanidin (PA), preserves demineralized dentin structure and enhances remineralization. This improves resin-dentin bonding and reduces dentin hypersensitivity in dental applications.
Area of Science:
- Biomaterials Science
- Dental Materials
- Biomineralization
Background:
- Demineralized dentin matrix is susceptible to degradation.
- Effective remineralization strategies are crucial for restorative dentistry.
- Crosslinking agents can improve the stability of the dentin matrix.
Purpose of the Study:
- To evaluate the impact of chemical crosslinking on demineralized dentin.
- To investigate the synergistic effects of crosslinking with calcium phosphate polymer-induced liquid precursor (CaP-PILP) remineralization.
- To assess the clinical relevance for resin-dentin bonding and dentin hypersensitivity.
Main Methods:
- Demineralized dentin was treated with glutaraldehyde (GA), carbodiimide (EDC), or procyanidin (PA).
- Crosslinked samples underwent CaP-PILP biomimetic remineralization.
- Evaluated morphology, mechanical properties, and enzyme resistance.
Main Results:
- GA and PA crosslinking maintained collagen fiber integrity and improved microhardness.
- PA crosslinking showed the strongest synergy with CaP-PILP remineralization, accelerating mineralization.
- Untreated dentin showed collagen degradation and open tubules, unlike crosslinked specimens.
Conclusions:
- GA and PA crosslinking significantly preserve dentin structure, enzyme resistance, and mechanical properties.
- PA exhibits strong synergistic effects with CaP-PILP for enhanced and accelerated bionic remineralization.
- Findings support improved clinical outcomes for resin-dentin bonding and dentin hypersensitivity.
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