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Validation of CHA2DS2 VASc Score Predictability of Stroke and Systemic Embolization in a Middle Eastern Population

Rasheed Ibdah1, Omar Obeidat1, Yousef Khader2

  • 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Vascular Health and Risk Management
|May 1, 2023
PubMed

Insights

The CHA2DS2-VASc score moderately predicts stroke and systemic embolism in Jordanian atrial fibrillation patients. The study suggests anticoagulation decisions should not consider gender.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Atrial fibrillation (Afib) poses a significant stroke risk.
  • The CHA2DS2-VASc score is crucial for risk stratification and treatment guidance in Afib patients.
  • Evaluating the score's predictive accuracy in diverse populations is essential.

Purpose of the Study:

  • To assess the predictive value of the CHA2DS2-VASc score for stroke and systemic embolism in the Jordanian Afib population.
  • To understand demographic and risk factors within this patient cohort.
  • To evaluate the effectiveness of anticoagulation in preventing adverse events.

Main Methods:

  • Analysis of 2020 patients from the Jordanian Atrial Fibrillation (JoFib) registry.
  • 1-year follow-up to record cerebrovascular accident (CVA) and systemic embolism (SE) events.
  • Bivariate, multivariate analyses, and ROC curve analysis to determine CHA2DS2-VASc score predictivity.

Main Results:

  • The study included 2020 Afib patients (mean age 67.8 years, 45.8% male).
  • A CHA2DS2-VASc score of ≥3 was observed in 71.8% of patients; 81.8% were on anticoagulants.
  • Moderate predictive power (C-statistic 0.689) for CVA/SE was found; 69 CVA and 9 SE events occurred within 1 year.

Conclusions:

  • The CHA2DS2-VASc score demonstrates moderate predictivity for stroke, SE, and all-cause mortality in this cohort.
  • Findings suggest that gender may not be a determining factor when initiating anticoagulant therapy.
  • This research provides valuable insights into Afib management within the Jordanian population.
Abstract

Keywords:
CHA2DS2-VAScJordanatrial fibrillationriskstroke

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