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Updated: Jul 31, 2025

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Catalytic Olefin-Imine Metathesis: Cobalt-Enabled Amidine Olefination with Enaminones
Shuaixin Fan1, Weiping Wu1, Lili Fang1
1Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, Jiangsu 210023, People's Republic of China.
Abstract:
Organic metathesis reactions allow for expedient assembly of diverse molecular skeletons and appendages through the exchange of molecular fragments. The olefin-imine variant of this process, in particular, can expand the synthetic toolbox for manipulating carbon-carbon and carbon-nitrogen bonds but has thus far been achieved only on a stoichiometric metal-mediated basis. Herein, we report the development of a catalytic olefin-imine metathesis reaction, featuring cobalt-catalyzed amidine olefination with enaminones and a versatile product synthon enabling further structural diversification.
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