iDPPIV-SI: identifying dipeptidyl peptidase IV inhibitory peptides by using multiple sequence information

Currently, diabetes has become a great threaten for people's health in the world. Recent study shows that dipeptidyl peptidase IV (DPP-IV) inhibitory peptides may be a potential pharmaceutical agent to treat diabetes. Thus, there is a need to discriminate DPP-IV inhibitory peptides from non-DPP-IV inhibitory peptides. To address this issue, a novel computational model called iDPPIV-SI was developed in this study. In the first, 50 different types of physicochemical (PC) properties were employed to denote the peptide sequences. Three different feature descriptors including the 1-order, 2-order correlation methods and discrete wavelet transform were applied to collect useful information from the PC matrix. Furthermore, the least absolute shrinkage and selection operator (LASSO) algorithm was employed to select these most discriminative features. All of these chosen features were fed into support vector machine (SVM) for identifying DPP-IV inhibitory peptides. The iDPPIV-SI achieved 91.26% and 98.12% classification accuracies on the training and independent dataset, respectively. There is a significantly improvement in the classification performance by the proposed method, as compared with the state-of-the-art predictors. The datasets and MATLAB codes (based on MATLAB2015b) used in current study are available at https://figshare.com/articles/online_resource/iDPPIV-SI/20085878.Communicated by Ramaswamy H. Sarma.