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Updated: Jul 31, 2025
09:16
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
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Methamphetamine exposure and depression-A systematic review and meta-analysis
Janni Leung1,2,3, Tesfa Mekonen1,2,4, XiaoXuan Wang1,2
1National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, Australia.
Drug and Alcohol Review
|May 1, 2023
Summary
Methamphetamine use significantly increases the odds of depression. This systematic review and meta-analysis found a clear link, with a low risk of unmeasured confounding in longitudinal data.
Area of Science:
- Public Health
- Mental Health
- Addiction Medicine
Background:
- Methamphetamine use is a significant public health issue.
- It is frequently associated with co-occurring mental health conditions, particularly depression.
- Understanding this relationship is crucial for effective intervention strategies.
Approach:
- A systematic review and meta-analysis adhering to PRISMA guidelines.
- Searched EMBASE, PsycINFO, and PubMed for human studies on methamphetamine/amphetamine use and depression.
- Assessed unmeasured confounding using E-value analyses.
Key Points:
- 14 studies were included, revealing a significant association between methamphetamine use and depression.
- Cross-sectional estimates showed an odds ratio (OR) of 1.66 (95% CI 1.34–2.05).
- Longitudinal estimates indicated an OR of 1.18 (95% CI 1.08–1.28), with higher odds for those with a methamphetamine use disorder (OR = 2.80, 95% CI 1.40–5.90).
Conclusions:
- Individuals using methamphetamine exhibit higher odds of depression.
- Longitudinal study results demonstrated a low to moderate risk of unmeasured confounding.
- Further research using causal framework methods is recommended to solidify findings.
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