Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon.

bioRxiv : the preprint server for biology·2026
Same author

Barrier Function of the Extracellular Matrix in AAV Gene Therapy.

Cellular and molecular bioengineering·2026
Same author

Myeloperoxidase impairs mucociliary transport on human airway epithelium.

Disease models & mechanisms·2026
Same author

Synthetic mucus biomaterials enable localized therapeutic antibody delivery in inflammatory bowel disease.

APL bioengineering·2026
Same author

Functional divergence of MdpS and MdpS2 reveals mucin-targeting strategies in <i>Streptococcus oralis</i>.

Journal of oral microbiology·2025
Same author

Methods for Discerning the Impact of Mucus on Host Defenses Against Viral Infection.

Current protocols·2025

Related Experiment Video

Updated: Jun 28, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.4K

Hydrogels for Mucosal Drug Delivery.

Taj Yeruva1, Sydney Yang1, Shadin Doski1

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.

ACS Applied Bio Materials
|May 1, 2023
PubMed
Summary

Hydrogels offer a promising solution for local drug delivery to mucosal tissues, improving therapeutic bioavailability for various conditions. This technology addresses challenges in delivering drugs effectively to the eye, nose, and other mucosal sites.

Keywords:
drug deliveryhydrogelsinfectious diseaseinflammatory diseasemucosa

More Related Videos

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.2K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.0K

Related Experiment Videos

Last Updated: Jun 28, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.4K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.2K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.0K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Immunology

Background:

  • Mucosal tissues are key sites for drug action and immune engagement.
  • Systemic drug administration often results in poor bioavailability at mucosal sites.
  • Effective local drug delivery technologies are needed for mucosal tissues.

Purpose of the Study:

  • To review hydrogels as a viable technology for local drug delivery to mucosal tissues.
  • To discuss key parameters for hydrogel-based mucosal drug delivery.
  • To highlight recent applications of hydrogels for mucosal diseases.

Main Methods:

  • Literature review of hydrogel applications in mucosal drug delivery.
  • Analysis of barriers and parameters for effective mucosal delivery.
  • Case studies of hydrogels for inflammatory and infectious mucosal diseases.

Main Results:

  • Hydrogels are identified as an attractive platform for local therapeutic delivery to diverse mucosal tissues.
  • Key parameters influencing hydrogel performance in mucosal environments are outlined.
  • Recent advancements showcase hydrogel efficacy in treating mucosal inflammatory and infectious diseases.

Conclusions:

  • Hydrogels represent a significant advancement in localized drug delivery for mucosal tissues.
  • The technology holds potential for treating a wide range of conditions affecting the eye, nose, oral cavity, gastrointestinal tract, bladder, and vagina.
  • Further research and application of hydrogels can improve therapeutic outcomes for mucosal diseases.