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Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data

William J Hulme1, Elizabeth Williamson2, Elsie M F Horne3

  • 1The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (W.J.H., A.G., A.J.W., H.J.C., C.E.M., B.M., R.C., A.M., S.B., D.E., P.I., S.D., B.G.).

Annals of Internal Medicine
|May 1, 2023
PubMed
Summary

Observational studies using target trial emulation can provide robust evidence on COVID-19 vaccine effectiveness. This method addresses biases in real-world data to inform clinical and policy decisions.

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