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Published on: October 8, 2014
Cold sensory transduction through the STIM-Orai signaling pathway
Yandong Zhou1, Michelle R Jennette1, Donald L Gill1
1Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, United States of America.
Abstract:
The STIM-Orai signaling pathway mediates Ca2+ signals vital for controlling transcription and cell growth. The Ca2+ sensing STIM proteins are activated by depletion of Ca2+ stored in the ER, and translocate into ER-PM junctions to gate PM Orai channels. STIM1 activation also results from heating STIM1 proteins, and new evidence reveals the STIM1-mediated gating of Orai1 channels is activated by noxious cooling of cells. This activation of the STIM-Orai pathway may be important in mediating vascular dilation that occurs in response to severe cold exposure.
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