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Does depression mediate the pain-frailty relationship? Latent variables approach
José M Tomás1, Trinidad Sentandreu-Mañó2, Sara Martínez-Gregorio1
1Department of Methodology for the Behavioral Sciences, University of Valencia, Valencia, Spain.
Geriatric Nursing (New York, N.Y.)
|May 1, 2023
Summary
In older adults, pain and depression significantly contribute to frailty. Depression partially mediates the relationship between pain and frailty, highlighting the importance of addressing both conditions.
Area of Science:
- Gerontology
- Psychiatry
- Epidemiology
Background:
- Frailty is a common condition in older adults, significantly impacting health and quality of life.
- The relationship between pain, depression, and frailty requires further elucidation.
Purpose of the Study:
- To investigate the mediational role of depression in the association between pain and frailty among Spanish older adults.
- To examine the direct and indirect effects of pain and depression on frailty.
Main Methods:
- Utilized data from 2578 Spanish older adults from the Survey of Health, Aging, and Retirement in Europe (SHARE).
- Employed structural equation modeling (SEM) to compare independent prediction, full mediation, and partial mediation models.
- Extended the best-fitting model to include relevant covariates.
Main Results:
- A partial mediation model demonstrated the best fit for the data.
- Both pain and depression showed significant effects on frailty in the final model.
- The combined effects of pain and depression explained 91% of the variance in frailty.
Conclusions:
- Depression plays a partial mediational role in the relationship between pain and frailty.
- The pain-depression dyad is critically important in the development of frailty.
- Understanding this interplay is crucial for developing effective interventions for frailty.
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