Related Experiment Video

Updated: Jul 31, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.1K

Prevalence of respiratory pathogens and risk of developing pneumonia under non-pharmaceutical interventions in

Ting Shi1, Linlin Huang1

  • 1Pediatric Intensive Care Unit, Department of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.

Epidemiology and Infection
|May 1, 2023
PubMed

Insights

Non-pharmaceutical interventions (NPIs) impacted pathogen prevalence in hospitalized children with acute respiratory infections (ARIs). Human rhinovirus (HRV) became most common, while Mycoplasma pneumoniae (MP) posed the highest pneumonia risk.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Virology
  • Epidemiology

Background:

  • Acute Respiratory Infections (ARIs) are a significant cause of childhood hospitalization.
  • Understanding pathogen prevalence and risk factors for complications like pneumonia is crucial for public health.
  • The impact of non-pharmaceutical interventions (NPIs) on pediatric respiratory pathogen dynamics requires investigation.

Purpose of the Study:

  • To evaluate the effect of NPIs on the prevalence of various respiratory pathogens in hospitalized children with ARIs.
  • To identify the most common respiratory pathogens and their seasonal and age-specific distribution.
  • To determine risk factors associated with the progression of respiratory infections to pneumonia.

Main Methods:

  • Retrospective analysis of 10,396 children under 16 hospitalized with ARIs between September 2021 and December 2022.
  • Multiplex PCR assays were used to detect 13 different respiratory pathogens.
  • Demographic data, pathogen test results, and diagnostic information were collected and analyzed.

Main Results:

  • Human rhinovirus (HRV) was the most prevalent pathogen (23.3%) following NPI implementation.
  • Other common pathogens included human respiratory syncytial virus (HRSV, 15.9%) and human metapneumovirus (HMPV, 10.5%).
  • Mycoplasma pneumoniae (MP), HMPV, Bocavirus, and HRSV were significantly associated with developing pneumonia.

Conclusions:

  • NPIs altered the landscape of respiratory pathogens in hospitalized children, with HRV becoming dominant.
  • Mycoplasma pneumoniae (MP) demonstrated the highest risk of progression to pneumonia among the studied pathogens.
  • Age and seasonality play distinct roles in the prevalence of specific respiratory viruses and bacteria.

Keywords:
ChildrenNPIsepidemiologypathogenspneumonia

More Related Videos

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

485
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

2.6K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
289
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.3K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
295
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
405
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
373
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
736