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Updated: Jul 31, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad1, Veronique Seidel2, Michalak Izabela3

  • 1Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com.

Cell Communication and Signaling : CCS
|May 1, 2023
PubMed

Insights

Phenolic compounds from plants show anticancer properties by inhibiting the Nrf2 pathway, which is crucial in cancer progression and therapy resistance. This review covers their potential as therapeutic agents.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer is a major global health concern, often linked to oxidative stress.
  • The transcription factor Nrf2 plays a key role in cellular defense against oxidative stress, influencing cancer growth, progression, and treatment resistance.
  • Inhibiting Nrf2 is a promising therapeutic strategy for cancer treatment.
Keywords:
ApoptosisCancerCytotoxicityNrf2Oxidative stressPhenolic compounds

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