Significant exercise limitations after recovery from MIS-C related myocarditis

Related Experiment Video

Updated: Jul 31, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.3K

Gur Mainzer1,2,3, Merav Zucker-Toledano4, Moneera Hanna5

  • 1Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, 52621, Tel Hashomer, Israel. gurmainzer@gmail.com.

World Journal of Pediatrics : WJP
|May 1, 2023
PubMed

Insights

Children recovering from multisystemic inflammatory syndrome (MIS-C) related myocarditis may experience exercise limitations. Cardiopulmonary exercise testing (CPET) is recommended for assessing functional capacity before returning to physical activity post-MIS-C.

Area of Science:

  • Pediatrics
  • Cardiology
  • Infectious Diseases

Background:

  • Myocarditis is a manifestation of multisystemic inflammatory syndrome in children (MIS-C) post-COVID-19.
  • While short-term outcomes are generally good, medium-term functional capacity data in recovered children are limited.

Purpose of the Study:

  • To evaluate exercise capacity in children who have recovered from MIS-C related myocarditis.
  • To identify potential cardiac and respiratory limitations affecting functional capacity.

Main Methods:

  • Fourteen children recovered from MIS-C related myocarditis underwent spirometry and cardiopulmonary exercise testing (CPET).
  • Results were compared to a matched control group of healthy children (n=14).

Main Results:

  • Peak oxygen uptake was within normal ranges for both groups.
  • However, 35% of post-MIS-C patients exhibited exercise-related cardio-respiratory abnormalities, including oxygen desaturation and reduced oxygen pulse.
  • The MIS-C group showed lower peak exercise saturation and breathing reserve compared to controls.

Conclusions:

  • Children recovering from MIS-C related myocarditis may experience exercise limitations.
  • Functional assessment using CPET is crucial before clearing patients for physical activity.
  • Further research with larger cohorts and longer follow-up is needed to understand physiological mechanisms.
Abstract

Keywords:
COVID 19Cardiopulmonary exercise testingHypoxemiaMyocarditis

More Related Videos

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol08:21

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol

Published on: June 8, 2017

7.8K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K

Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
10
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
14
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
883
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
20
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
14
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
20