Related Experiment Video
Updated: Jul 31, 2025

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
Published on: October 26, 2010
Organophosphate Toxicity Presenting as a Stroke Alert
Martin J Morales-Cruz1, Bridget Scheveck1, Vanessa I Diaz1
1Emergency Medicine, HCA Florida Osceola Hospital, Kissimmee, USA.
Altered mental status can mimic stroke. Organophosphate poisoning, though rare, should be considered in patients with miosis and bradycardia unresponsive to naloxone.
Area of Science:
- Toxicology
- Emergency Medicine
- Neurology
Background:
- Altered mental status (AMS) is a frequent emergency department (ED) presentation with a wide differential diagnosis.
- Diagnosing AMS is challenging when patients cannot provide a history and collateral information is limited.
Observation:
- A case of AMS initially suspected as a stroke alert was presented.
- The patient's condition was later identified as intentional organophosphate ingestion.
Findings:
- Organophosphate poisoning, while uncommon in the U.S., presents with specific signs.
- Key indicators include miosis, bradycardia, and copious secretions.
- Patients with these symptoms unresponsive to naloxone warrant consideration for organophosphate toxicity.
Implications:
- This case highlights the importance of considering less common toxicological causes of AMS.
- Early recognition of organophosphate poisoning is crucial for appropriate management and improved patient outcomes.
- Clinicians should maintain a broad differential for AMS, including toxic ingestions.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Parkinson's Disease: Overview
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they...

