[Chronophysiological study of the effect of alcohol on the cardiovascular system of healthy humans]

Variation of 13 cardiovascular parameters was examined in 30 normal volunteers aged 21 to 26 years through the day before the use of alcohol and three daily cycles after a single dose of alcohol producing moderate intoxication with blood ethanol levels reaching 1.87 +/- 0.03 g/l. A circadian temporal pattern was demonstrated in cardiovascular activity, that was disrupted by alcohol action. The effects of alcohol on some hemodynamic parameters were not identical after different postalcoholization time intervals. Most of the parameters examined returned to normal as soon as ethanol was eliminated from the body, i.e. within 13 to 15 hours, while other parameters took more time to normalize. Biorhythmologic shifts could be seen for two daily cycles, and the circadian pattern was resumed by day 3 following the use of alcohol.