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Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
Published on: May 26, 2023
Medium-Term Outcomes in Pediatric Patients Undergoing Cardiac Catheterization Early After Congenital Cardiac Surgery
Kamel Shibbani1, Jess T Randall2, Bassel Mohammad Nijres1
1Division of Pediatric Cardiology, Stead Family Children's Hospital, University of Iowa, Iowa City, IA, USA.
Insights
Mid-term outcomes after early cardiac catheterization in infants following congenital heart surgery show frequent re-interventions. Renal failure, younger age, and inotropic support at catheterization predict worse outcomes.
Area of Science:
- Pediatric Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Established acute outcomes for post-congenital cardiac surgery catheterization.
- Limited data exists on mid-term outcomes for this patient population.
Purpose of the Study:
- To evaluate mid-term outcomes in patients undergoing cardiac catheterization within six weeks of congenital cardiac surgery.
- To identify factors associated with adverse mid-term outcomes.
Main Methods:
- Retrospective cohort study of 99 patients undergoing cardiac catheterization within six weeks of congenital cardiac surgery.
- Longitudinal follow-up assessing mid-term outcomes, including death, transplant, and re-interventions.
- Multivariable analysis to identify predictors of adverse outcomes.
Main Results:
- 61% of survivors were free from the primary endpoint (death/transplant) at a median follow-up of 4.24 years.
- 69.7% of patients required an unplanned surgical or catheter re-intervention.
- Renal failure, inotropic medication use, and younger age at catheterization were significantly associated with adverse outcomes.
Conclusions:
- Patients undergoing early postoperative cardiac catheterization face frequent re-interventions.
- Renal failure, younger age, and need for inotropic support are significant predictors of adverse mid-term outcomes.
- While hospital survival is favorable, ongoing management and re-interventions are common.
Abstract:
Safety and acute outcomes for patients who need catheterization shortly after congenital cardiac surgery has been established; literature on mid-term outcomes is lacking. We sought to evaluate the mid-term outcomes of patients who undergo early postoperative cardiac catheterization. This is a retrospective cohort study of patients who underwent cardiac catheterization within 6 weeks of congenital cardiac surgery with longitudinal follow-up and assessment of mid-term outcomes. Multivariable analysis was utilized to relate variables of interest to outcomes. 99 patients underwent cardiac catheterizations within 6 weeks of cardiac surgery between January 2008 and September 2016. Forty-six (45.5%) interventional procedures were performed at a median age of 41 days (IQR 21-192) and a median weight of 3.9 kg (3.3-6.6). During a median follow-up duration of 4.24 years (1.6-5.6) in study survivors, 61% of patients remained free from the primary endpoint (death and/or transplant). Sixty-nine patients (69.7%) underwent an unplanned surgical or catheter procedure. Renal failure at catheterization (OR 280.5, p 0.0199), inotropic medication at catheterization (OR 14.8, p 0.002), and younger age were all significantly associated with meeting the primary endpoint. Patients requiring surgical intervention as an initial additional intervention underwent more unplanned re-interventions, while patients who survived to hospital discharge demonstrated favorable mortality, though with frequent need for re-intervention. In patients requiring early postoperative cardiac catheterization, renal failure, younger age, and need for inotropic support at catheterization are significantly associated with meeting the primary endpoint.
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