Related Experiment Video

Updated: Jul 31, 2025

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

6.0K

SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022)

César Serrano1, Rosa Álvarez2, Juan Antonio Carrasco3

  • 1Sarcoma Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitario Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, C/Natzaret, 115-117, 08035, Barcelona, Spain. cserrano@vhio.net.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|May 2, 2023
PubMed

Insights

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms. Targeted therapies like tyrosine kinase inhibitors have significantly improved survival for GIST patients, transforming treatment outcomes.

Area of Science:

  • Oncology
  • Medical Genetics
  • Pharmacology

Background:

  • Gastrointestinal stromal tumor (GIST) represents the most frequent mesenchymal malignancy.
  • GIST serves as a key model for targeted cancer therapy development.
  • Tyrosine kinase inhibitors targeting KIT/PDGFRA have revolutionized GIST treatment.

Purpose of the Study:

  • To provide updated, multidisciplinary consensus guidelines for GIST diagnosis and treatment.
  • To establish recommendations for managing GIST patients.

Main Methods:

  • Conjoint elaboration by the Spanish Society of Medical Oncology (SEOM) and the Spanish Sarcoma Research Group (GEIS).
  • Development of consensus-based guidelines for GIST management.

Main Results:

  • Introduction of KIT/PDGFRA-active tyrosine kinase inhibitors has markedly improved survival in localized and advanced GIST.
  • These targeted therapies offer effective systemic treatment for a previously resistant disease.

Conclusions:

  • Management of GIST patients should be centralized in reference centers.
  • Multidisciplinary team involvement is crucial for optimal GIST patient care.
Keywords:
AvapritinibGISTImatinibRipretinib

More Related Videos

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.1K

Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
127
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
228
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
345
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
179
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
120
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K