Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmid DNA vaccines encapsulated in lipid nanoparticles elicit STING-dependent type 1 interferon release.

Molecular therapy. Advances·2026
Same author

Balloon Pulmonary Angioplasty for Treatment of Chronic Thromboembolic Pulmonary Hypertension: Statement From the BPA-CTEPH Alliance.

JACC. Cardiovascular interventions·2026
Same author

Therapeutic innovations in triple negative breast cancer: integrating molecular targeting and monoclonal antibody strategies.

Frontiers in oncology·2025
Same author

Magnetic Capture of Autologous Mesenchymal Stem Cells Promotes the Rapid Endothelialization of Peripheral Venous Stents in Rabbits.

Acta biomaterialia·2025
Same author

Evaluation of FeMnN alloy bioresorbable flow diverting stents in the rabbit abdominal aorta.

Bioactive materials·2025
Same author

Magnetic capture of blood outgrowth endothelial cells to the luminal surface of magnetizable stent-grafts promotes healing in a porcine pseudoaneurysm model.

Acta biomaterialia·2025

Related Experiment Video

Updated: Jul 31, 2025

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.2K

Magnetic and Biocompatible Polyurethane Nanofiber Biomaterial for Tissue Engineering.

Joshua A Choe1, Susheil Uthamaraj2, Dan Dragomir-Daescu3

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Tissue Engineering. Part A
|May 2, 2023
PubMed
Summary

A new magnetic composite biomaterial using polyurethane and stainless steel enables targeted endothelial cell capture for cardiovascular devices. This innovation improves site-specific cell localization, addressing issues like thrombosis and restenosis.

Keywords:
electrospinningmagnetic biomaterialsmagnetic cell targetingnanofibersvascular stent-grafts

More Related Videos

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.1K
Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

15.5K

Related Experiment Videos

Last Updated: Jul 31, 2025

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.2K
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.1K
Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

15.5K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cardiovascular Engineering

Background:

  • Cardiovascular device surfaces face challenges like thrombosis and neointimal hyperplasia.
  • Current cell targeting strategies often lack specificity for in vivo applications.
  • Superparamagnetic iron oxide nanoparticles offer potential for targeted cell localization.

Purpose of the Study:

  • To develop a magnetic polyurethane (PU)-2205 stainless steel (2205-SS) nanofibrous composite biomaterial.
  • To evaluate the material's properties and its efficacy in magnetic cell capture for stent-graft applications.
  • To assess the cytocompatibility of the novel composite material.

Main Methods:

  • Electrospinning of PU and 2205-SS microparticles at varying ratios (0-4:1).
  • Fabrication of stent-grafts with magnetic or nonmagnetic stents using the optimal composite ratio (2:1).
  • Characterization via microscopy, mechanical testing, sessile drop test, magnetic field measurement, cell capture assays, and 14-day endothelial cell culturing.

Main Results:

  • An optimal 2:1 2205-SS:PU ratio yielded a hydrophobic material with balanced mechanical and magnetic properties.
  • The composite material demonstrated cytocompatibility with endothelial cells for up to 14 days.
  • Significant cell capture was achieved with a 0.5 mm thick material, and magnetic stent-grafts showed uniform cell distribution.

Conclusions:

  • The developed magnetic PU-2205 SS nanofibrous composite is a promising biomaterial for cardiovascular applications.
  • The material enables site-specific magnetic capture of endothelial cells and potentially other therapeutic agents.
  • This technology holds potential for advancing vascular and tissue engineering applications through improved device integration and cell targeting.