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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Coronavirus Disease 2019, Diabetes, and Inflammation: A Systemic Review

Monique Ferguson1,2, Jaysonn Vel1, Vincent Phan1

  • 1John Sealy School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA.

Metabolic Syndrome and Related Disorders
|May 2, 2023
PubMed

Insights

People with cardiometabolic diseases like type 2 diabetes and obesity face higher risks from COVID-19 infection, experiencing severe illness and poorer outcomes due to hyperinflammation. Managing inflammation and blood sugar is key for better clinical results.

Area of Science:

  • Immunology
  • Endocrinology
  • Infectious Diseases

Background:

  • Cardiometabolic diseases, including type 2 diabetes (T2D) and obesity, are linked to increased susceptibility and severity of coronavirus disease 2019 (COVID-19).
  • Hyperinflammation is a proposed shared pathway contributing to poor outcomes in both cardiometabolic diseases and COVID-19.

Purpose of the Study:

  • To investigate the role of shared inflammatory biomarkers between COVID-19 and cardiometabolic diseases.
  • To evaluate the impact of cardiometabolic conditions on COVID-19 prognosis.

Main Methods:

  • Systematic review and evaluation of published data from PubMed, SCOPUS, and WHO COVID-19 databases.
  • Inclusion of English articles published from December 2019 to February 2022, with 50 articles selected from 248 identified.

Main Results:

  • Individuals with diabetes or obesity exhibit an increased risk of COVID-19 infection, hospitalization, and mortality.
  • Diabetic patients face a higher risk of intensive care unit admission.
  • COVID-19 infection can increase the risk of developing T2D, particularly in patients with comorbidities, due to heightened inflammatory responses (hyperinflammation).

Conclusions:

  • Hyperinflammation exacerbates COVID-19 prognosis in patients with cardiometabolic diseases.
  • Controlling blood glucose and ameliorating inflammatory responses are crucial for improving clinical outcomes.
  • Clinical evaluation of hyperinflammatory states is critical for managing COVID-19 patients with cardiometabolic conditions.

Keywords:
COVID-19SARS-CoV-2inflammationmetabolic syndromeobesitytype 2 diabetes

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