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Mitochondria-derived vesicles and their potential roles in kidney stone disease

Sakdithep Chaiyarit1, Visith Thongboonkerd2

  • 1Medical Proteomics Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, 6th Floor, SiMR Building, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Journal of Translational Medicine
|May 2, 2023
PubMed

Insights

Mitochondria-derived vesicles (MDVs) are key in mitochondrial quality control (MQC), clearing damaged components. This review explores MDV roles in health, disease, and potential kidney stone disease (KSD) applications.

Area of Science:

  • Cell Biology
  • Mitochondrial Biology
  • Molecular Medicine

Background:

  • Mitochondria-derived vesicles (MDVs) are emerging players in mitochondrial quality control (MQC).
  • MDVs transport damaged mitochondrial components (mtDNA, proteins, lipids) for clearance under stress.
  • Their role is crucial when other MQC pathways like mitophagy or dynamics (fission/fusion) are insufficient.

Purpose of the Study:

  • To review current knowledge on MDVs and their functions in MQC.
  • To discuss the physiological and pathophysiological roles of MDVs.
  • To emphasize the potential clinical relevance of MDVs in kidney stone disease (KSD) therapeutics and diagnostics.

Main Methods:

  • Literature review of studies on MDVs and MQC.
  • Analysis of MDV biogenesis and cargo under different stress conditions.
  • Evaluation of MDV involvement in various physiological and pathological states.

Main Results:

  • MDVs are essential for removing damaged mitochondrial parts, maintaining cellular homeostasis.
  • MDV formation is induced by mild stress and also acts as a backup MQC mechanism.
  • Evidence suggests MDVs are implicated in the pathophysiology of kidney stone disease.

Conclusions:

  • MDVs represent a significant component of the MQC system, vital for mitochondrial health.
  • Understanding MDV function offers insights into cellular stress responses and disease mechanisms.
  • MDVs hold promise for novel diagnostic and therapeutic strategies in kidney stone disease.
Keywords:
EVsExtracellular vesiclesMDVsMitovesiclesNephrolithiasisOxidative stressUrolithiasis

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