Related Experiment Video
Updated: Jul 31, 2025

Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Prior metabolic surgery reduced COVID-19 severity: Systematic analysis from year one of the COVID-19 pandemic
G Craig Wood1, Peter N Benotti1, Rodrigo M Fano2
1Obesity Institute, Geisinger, Danville, PA, USA.
Background:
Obesity is a risk factor for COVID-19 severity. Recent studies suggest that prior metabolic surgery (MS) modifies the risk of COVID-19 severity.
Methods:
COVID-19 outcomes were compared between patients with MS (n = 287) and a matched cohort of unoperated patients (n = 861). Multiple logistic regression was used to identify predictors of hospitalization. A systematic literature review and pooled analysis was conducted to provide overall evidence of the influence of prior metabolic surgery on COVID-19 outcomes.
Results:
COVID-19 patients with MS had less hospitalization (9.8% versus 14.3%, p = 0.049). Age 70+, higher BMI, and low weight regain after MS were associated with more hospitalization after COVID-19. A systematic review of 7 studies confirmed that MS reduced the risk of post-COVID-19 hospitalization (OR = 0.71, 95%CI = [0.61-0.83], p < 0.0001) and death (OR = 0.44, 95%CI = [0.30-0.65], p < 0.0001).
Conclusion:
MS favorably modifies the risks of severe COVID-19 infection. Older age and higher BMI are major risk factors for severity of COVID-19 infection.
Related Concept Videos
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Cardiomyopathy VII: Pre and Post Operative Nursing Management
Metabolic States of the Body: Fasting and Starvation
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Chronic Pancreatitis II: Collaborative Care
Assessment:

