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DNA-m6A calling and integrated long-read epigenetic and genetic analysis with fibertools
Anupama Jha1, Stephanie C Bohaczuk2, Yizi Mao2
1Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Biorxiv : the Preprint Server for Biology
|May 3, 2023
Summary
Introducing fibertools, a new toolkit for long-read DNA sequencing. It accurately identifies DNA N-methyladenine modifications and integrates genetic and epigenetic data, improving speed and analysis of complex genomic regions.
Area of Science:
- Genomics
- Epigenetics
- Bioinformatics
Background:
- Long-read DNA sequencing offers single-molecule resolution for genetic and epigenetic studies.
- Detecting DNA N-methyladenine (DNA-m6A) and integrating genetic/epigenetic data is computationally challenging.
- Existing tools lack comprehensive support for co-processing diverse long-read data.
Conclusions:
- Fibertools provides a fast and accurate solution for DNA-m6A detection using long-read sequencing.
- The toolkit enables seamless integration of genetic and epigenetic data, enhancing genomic analyses.
- Fibertools supports analysis in complex genomic regions, including structurally and somatically variable areas.
