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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Translational Regulation01:29

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Updated: Jul 31, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial transcriptome profiling uncovers metabolic regulation of left-right patterning.

Hisato Yagi, Cheng Cui, Manush Saydmohammed

    Biorxiv : the Preprint Server for Biology
    |May 3, 2023
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    Summary

    Metabolic processes, particularly glycolysis, unexpectedly regulate left-right body patterning. This discovery may explain birth defects linked to maternal diabetes and offers new avenues for research.

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    Area of Science:

    • Developmental Biology
    • Metabolic Regulation
    • Birth Defects Research

    Background:

    • Left-right patterning is crucial for development but poorly understood.
    • Disturbances in this process lead to severe congenital anomalies.

    Conclusions:

    • Metabolic regulation, specifically glycolysis, plays a critical role in establishing left-right body asymmetry.
    • Findings provide a potential mechanism for heterotaxy-related birth defects in maternal diabetes.
    • The PFKP gene's association with heterotaxy supports the role of glycolysis regulation.