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Updated: Jul 31, 2025

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration

Hannah M Olson1,2, Amanda Maxfield1, Nicholas L Calistri3,4

  • 1Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, The Knight Cancer Institute, Portland, Oregon, USA.

Biorxiv : the Preprint Server for Biology
|May 3, 2023
PubMed
Summary

The RhoA GEF Mcf2lb protein is crucial for maintaining rosette integrity during zebrafish development. Loss of Mcf2lb disrupts cell apical constriction, leading to excess sensory organ formation.

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