Copper-catalyzed one-pot [3 + 2] cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones
Qing-Qiang Su1, Ruo-Nan Wang1, Yong-Zheng Lv1
1College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, China. huanghongli@lcu.edu.cn.
Abstract:
Fused furans are commonly found units in natural products and medicinal molecules, and methods for their introduction are of fundamental importance. Here we report one-pot cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones enabled by copper catalysis, leading to a series of functionalized furan derivatives in good yields. This method features mild reaction conditions, high efficiency, and wide substrate scope.
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