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Cardiovascular organ damage in relation to hypertension status in patients with ankylosing spondylitis

Gyda Ullensvang1, Ester Kringeland1,2, Eirik Ikdahl3

  • 1Center for research on cardiac disease in women, Department of Clinical Science, University of Bergen, Bergen, Norway.

Blood Pressure
|May 3, 2023
PubMed

Insights

Hypertension significantly increases cardiovascular organ damage risk in ankylosing spondylitis (AS) patients. Aggressive hypertension management is crucial for AS patients to prevent CV complications.

Area of Science:

  • Cardiology
  • Rheumatology
  • Vascular Medicine

Background:

  • Hypertension is a primary cardiovascular risk factor in ankylosing spondylitis (AS).
  • Cardiovascular (CV) organ damage prevalence concerning hypertension status in AS patients is understudied.

Purpose of the Study:

  • To assess the prevalence of CV organ damage in relation to hypertension in AS patients.
  • To determine the association between hypertension and CV organ damage in AS.

Main Methods:

  • 126 AS patients and 71 controls underwent echocardiography, carotid ultrasound, and pulse wave velocity (PWV) measurements.
  • CV organ damage was defined by abnormal left ventricular geometry, diastolic dysfunction, left atrial dilatation, carotid plaque, or high PWV.

Main Results:

  • 34% of AS patients had hypertension, with higher CRP levels compared to normotensive AS patients and controls.
  • CV organ damage prevalence was 84% in hypertensive AS patients, 29% in non-hypertensive AS patients, and 30% in controls.
  • Hypertension was independently associated with a fourfold increased risk of CV organ damage in AS patients (OR 4.57).

Conclusions:

  • CV organ damage in AS is strongly linked to hypertension.
  • Guideline-based hypertension management is essential for AS patients to mitigate CV risk.
Abstract

Keywords:
Ankylosing spondylitisarterial stiffnesscardiovascular organ damagecarotid ultrasoundechocardiographyhypertension

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