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The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

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Fas (CD95)/FasL (CD178) system during ageing.

Francisco A Lagunas-Rangel¹

¹Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.

Cell Biology International

|May 3, 2023

Summary

The Fas/FasL system is crucial for apoptosis and its dysregulation contributes to age-related diseases. Lifestyle interventions like exercise and diet can positively modulate this system for healthier aging.

Keywords:

aging/senescence apoptosis biochemistry diseases immunology

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Area of Science:

Immunology
Cell Biology
Gerontology

Background:

The Fas/FasL system regulates apoptosis and is linked to immune diseases and cancer.
Its role in aging and age-related diseases is increasingly recognized.
Deregulation of Fas/FasL is associated with conditions like osteoarthritis, diabetes, and Alzheimer's disease.

Purpose of the Study:

To detail changes in the Fas/FasL system during aging.
To explore the link between Fas/FasL system alterations and age-related diseases.
To examine the impact of exercise and diet on the Fas/FasL system in aging.

Main Methods:

Literature review and synthesis of existing research on the Fas/FasL system and aging.
Analysis of studies investigating the association between Fas/FasL and age-related pathologies.
Examination of evidence regarding lifestyle interventions' effects on the Fas/FasL pathway.

Main Results:

The Fas/FasL system undergoes significant changes with age.
These changes contribute to the pathogenesis of various age-related diseases.
Exercise and diet demonstrate a regulatory effect on the Fas/FasL system.

Conclusions:

The Fas/FasL system is a key player in the aging process.
Modulating the Fas/FasL system through lifestyle choices may mitigate age-related diseases.
Targeting the Fas/FasL pathway offers potential for healthy aging strategies.