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Five- and 10-year survival in extramammary Paget's disease: A focus on wide local excision
Dae-Lyong Ha1, Gi Ung Ha1, Jun Young Kim1
1Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Aim:
This study aimed to analyze extramammary Paget's disease (EMPD)-specific survival, overall survival, and recurrence rate (RR) in patients with EMPD in South Korea, with a focus on wide local excision.
Methods:
We retrospectively reviewed the medical records of patients with EMPD from 1993 to 2020 at Kyungpook National University Hospital. We determined the survival and RRs after wide local excision.
Results:
A total of 95 patients (66 males and 29 females; mean age 67.4 years) were included. The 5-year disease-specific survival and overall survival were 91.8% and 79.3%, respectively, whereas the 10-year rates were 81.6% and 64.7%, respectively. No significant sex differences were observed. Seventy-five patients (78.9%) underwent wide local excision. Mucosal involvement and lymphadenopathy were identified as the significant prognostic factors of disease-specific survival in multivariate analysis. The RR was 14.7% in patients who underwent wide local excision: seven local, two regional, and two distant metastases, with a mean recurrence-free interval of 42.3 months.
Conclusion:
Based on the survival and RRs obtained, surgical treatment of EMPD with wide local excision provides fair curative resection.
Practitioner Points:
Wide local excision can be a feasible treatment option for extramammary Paget's disease.
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