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Microfluidic viscometer by acoustic streaming transducers.

Ruoyu Jiang1, Paul Yoo1, Abhinand M Sudarshana1

  • 1Biomedical Engineering, University of California, Irvine, CA 92697, USA.

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|May 3, 2023
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Summary
This summary is machine-generated.

A new microfluidic viscometer by acoustic streaming transducers (μVAST) measures fluid viscosity using acoustic microstreaming. This platform requires minimal sample volume and enables ultra-high throughput measurements for biomanufacturing and drug development.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Fluid Dynamics

Background:

  • Accurate viscosity measurement is crucial for biomanufacturing and therapeutic delivery of biologics like DNA, antibodies, and cell-based drugs.
  • The physical properties of biologics, including viscosity, significantly impact bioprocess optimization and patient treatment outcomes.
  • Existing viscometers often require large sample volumes, limiting their application in high-throughput or precious sample analysis.

Purpose of the Study:

  • To develop and validate a novel acoustic microstreaming platform for precise viscosity measurement.
  • To demonstrate the capability of the microfluidic viscometer by acoustic streaming transducers (μVAST) for analyzing various fluid viscosities.
  • To highlight the advantages of μVAST, including low sample volume requirement and potential for high-throughput analysis.

Main Methods:

  • Utilized acoustic microstreaming induced by acoustic streaming transducers to create fluid transport.
  • Developed a microfluidic viscometer by acoustic streaming transducers (μVAST) platform for viscosity determination.
  • Validated the platform using glycerol mixtures of varying concentrations to represent diverse viscosities.

Main Results:

  • Viscosity was accurately estimated by measuring the maximum speed of second-order acoustic microstreaming.
  • The μVAST platform demonstrated high precision with minimal sample volumes (approximately 1.2 μL), 16-30 times less than commercial viscometers.
  • Achieved ultra-high throughput measurement, analyzing 16 samples in just 3 seconds.

Conclusions:

  • The μVAST platform offers a sensitive, low-volume, and high-throughput method for fluid viscosity measurement.
  • This technology has significant potential for automating process flows in drug development and materials manufacturing.
  • μVAST provides a valuable tool for optimizing biomanufacturing processes and ensuring effective therapeutic delivery.