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Updated: Jul 31, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Nondisordered Cannabis Use Among US Adolescents
Ryan S Sultan1,2,3, Alexander W Zhang1,2, Mark Olfson1,2,4
1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.
Adolescents using cannabis without a disorder (NDCU) showed significantly higher odds of experiencing adverse psychosocial events compared to nonusers. This highlights risks associated with even subclinical cannabis use in youth.
Area of Science:
- Adolescent health
- Psychosocial outcomes
- Cannabis use research
Background:
- Cannabis use is increasingly perceived as low-risk by adolescents.
- While cannabis use disorder (CUD) is linked to adverse outcomes, the impact of nondisordered cannabis use (NDCU) is less understood.
- Adolescents with NDCU face increased risks for negative psychosocial events.
Purpose of the Study:
- To determine the prevalence and demographics of NDCU in adolescents.
- To compare the associations between cannabis use (nonuse, NDCU, CUD) and adverse psychosocial events.
- To investigate the relationship between subclinical cannabis use and negative psychosocial outcomes in youth.
Main Methods:
- A cross-sectional study utilizing a nationally representative sample from the 2015-2019 National Survey on Drug Use and Health.
- Analysis included 68,263 adolescents aged 12-17, categorized into nonuse, NDCU, and CUD groups.
- NDCU was defined as recent cannabis use not meeting DSM-5 CUD criteria; CUD was defined using DSM-5 criteria.
Main Results:
- NDCU was found in 10.2% of adolescents, approximately 4 times more prevalent than CUD (2.5%).
- Adolescents with NDCU had 2 to 4 times greater odds of experiencing adverse psychosocial events, including depression, suicidal ideation, and concentration difficulties.
- Prevalence of adverse events increased in a stepwise manner from nonuse to NDCU to CUD.
Conclusions:
- Past-year NDCU is significantly more prevalent than CUD among US adolescents.
- A clear gradient of increased risk for adverse psychosocial events exists from nonuse to NDCU to CUD.
- Further research on NDCU is crucial given the normalization of cannabis use in the US.
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