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Updated: Jul 23, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

7.2K

[Cerebral small vessel disease]

Leonardo Caranzano1, Patrik Michel1

  • 1Service de neurologie, Département des neurosciences cliniques, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.

Revue Medicale Suisse
|May 3, 2023
PubMed

Insights

Cerebral microangiopathy, a common cause of dementia, presents with varied symptoms despite similar imaging. Effective management focuses on controlling cerebrovascular risk factors.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroscience

Context:

  • Cerebral microangiopathy is a significant contributor to dementia, second only to Alzheimer's disease.
  • It acts as a co-factor in most dementia cases.
  • Clinical presentations are diverse, encompassing cognitive, neuropsychiatric, gait, and urinary issues, alongside strokes.

Purpose:

  • To highlight the varied clinical manifestations of cerebral microangiopathy.
  • To emphasize the role of sub-radiological neurovascular unit damage in symptom variability.
  • To underscore the importance of managing cerebrovascular risk factors for prevention and treatment.

Summary:

  • Cerebral microangiopathy leads to diverse neurological deficits and strokes.
  • Damage to the neurovascular unit, often unseen on conventional MRI, contributes to variable patient outcomes.
  • Despite varied presentations, effective management and prevention strategies exist.

Impact:

  • Improved understanding of cerebral microangiopathy's complex clinical spectrum.
  • Highlights the need for advanced imaging or diagnostic approaches to assess neurovascular unit integrity.
  • Promotes aggressive management of cerebrovascular risk factors for dementia prevention and treatment.

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