No increase in sister-chromatid exchange frequency in lymphocytes of chromium platers

To detect mutagenic effects of hexavalent chromium (Cr) in vivo, sister-chromatid exchange (SCE) frequency was analyzed in lymphocytes of 24 Cr platers occupationally exposed to hexavalent Cr and 24 matched controls. There were no significant differences in SCE frequency between the two groups. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers.