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Nanostructured chitosan-polyphenolic patch for remote NIR-photothermal controlled dermal drug delivery
Muntasir Rahman1, Fariha Chowdhury1, Kamal Uddin1
1Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
Summary
A new nanostructured dermal patch using chitosan-tannic acid and Indocyanine green dye can deliver antibiotics and generate heat with near-infrared light. This technology shows promise for sustained, on-demand wound healing and drug delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Dermatology
Background:
- Developing advanced drug delivery systems is crucial for effective wound management.
- Chitosan-tannic acid composites offer potential for controlled release and therapeutic applications.
- Near-infrared (NIR) responsive materials enable targeted therapies with minimal invasiveness.
Purpose of the Study:
- To synthesize and characterize a nanostructured dermal patch (CT-I) capable of near-infrared (NIR) light-induced photothermal activity.
- To evaluate the patch's ability to deliver topical antibiotic Neomycin (CT-I/N) in a dermal environment.
- To assess the potential of the developed patch for sustained wound healing.
Main Methods:
- Synthesis of chitosan-tannic acid (CT) nanostructured dermal patch loaded with Indocyanine green (ICG).
- Characterization using FTIR, SEM/EDX, TGA, and DSC analysis.
- In vitro drug release studies at physiological pH (5.5) and elevated temperatures.
- In vivo thermographic assessment of photothermal activity and wound healing evaluation via H&E staining.
Main Results:
- The CT-I/N patch demonstrated favorable in vitro drug release, increasing by 25% at 40-45°C.
- The patch exhibited significant photothermal heat generation (>45°C within 5 min) upon NIR irradiation (808 nm).
- In vivo studies showed sustained wound healing, evidenced by H&E staining of dermal tissue.
Conclusions:
- The developed NIR-active nanostructured patch (CT-I/N) is effective for on-demand topical antibiotic delivery.
- The photothermal properties enhance drug release and promote wound healing.
- This technology presents a promising platform for future sustained drug delivery systems.
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