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Updated: Jul 31, 2025

Author Spotlight: Advancements in CAR-T Cell Manufacturing and Gene Therapy Production
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Biomaterials for chimeric antigen receptor T cell engineering.

Huanqing Niu1, Penghui Zhao2, Wujin Sun3

  • 1Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China.

Acta Biomaterialia
|May 3, 2023
PubMed
Summary

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This summary is machine-generated.

Biomaterial engineering offers new ways to improve Chimeric antigen receptor T (CAR-T) cell therapy manufacturing and effectiveness. These innovations aim to lower costs and boost CAR-T cell performance, especially in solid tumors.

Area of Science:

  • Biomaterial engineering
  • Cancer immunotherapy
  • Cell therapy manufacturing

Background:

  • Chimeric antigen receptor T (CAR-T) cells show high efficacy in blood cancers but struggle with solid tumors.
  • High manufacturing costs and poor solid tumor penetration limit CAR-T cell therapy access and application.
  • Novel strategies are essential to overcome these limitations and expand CAR-T cell utility.

Purpose of the Study:

  • To review recent advancements in engineering biomaterials for CAR-T cell production and stimulation.
  • To explore biomaterial applications in simplifying CAR-T cell manufacturing and enhancing therapeutic efficacy.
  • To discuss the potential of biomaterials in reducing CAR-T cell costs and improving solid tumor treatment.

Main Methods:

  • Focus on engineering non-viral gene delivery nanoparticles for CAR transduction (ex vivo, in vitro, in vivo).
Keywords:
Chimeric antigen receptor T cell therapyImplantable scaffoldsNano-microparticlesNon-viral transduction

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  • Review of nano-/microparticles and implantable scaffolds for local CAR-T cell delivery and stimulation.
  • Analysis of biomaterial strategies developed over the past five years.

    • Main Results:

    • Biomaterial engineering provides alternative strategies to biological approaches for CAR-T cell improvement.
    • Engineered biomaterials can simplify CAR-T cell manufacturing processes, potentially reducing costs.
    • Biomaterials can modulate the tumor microenvironment to enhance CAR-T cell efficacy in solid tumors.

    Conclusions:

    • Biomaterial engineering holds significant promise for advancing CAR-T cell therapy.
    • These strategies can address manufacturing cost and efficacy challenges, broadening patient access.
    • Future research should focus on further optimizing biomaterial designs for enhanced CAR-T cell performance.