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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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Malnutrition and poststroke depression in patients with ischemic stroke
Mengmeng Gu1, Jinjing Wang2, Lulu Xiao2
1Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Journal of Affective Disorders
|May 3, 2023
Summary
Malnutrition increases the risk of post-stroke depression (PSD) and slows its decline. Body mass index (BMI) did not significantly affect PSD risk in stroke patients.
Area of Science:
- Neurology
- Nutritional Science
- Psychiatry
Background:
- Identifying high-risk patients for post-stroke depression (PSD) is crucial for effective intervention.
- Modifiable clinical characteristics, such as malnutrition, are key targets for reducing PSD risk.
Purpose of the Study:
- To investigate the impact of nutritional status on the risk of developing PSD.
- To analyze how nutritional status influences the trajectory of PSD risk over time.
Main Methods:
- An observational cohort study followed 538 acute ischemic stroke patients for 1 year.
- Multivariate logistic and multilevel mixed-effects models analyzed nutritional indexes (CONUT, NRI, PNI) and BMI effects on PSD risk and trajectory.
- Nutritional status was assessed using CONUT, NRI, PNI, and BMI.
Main Results:
- Worsening scores in CONUT, NRI, and PNI were significantly associated with increased incident PSD risk.
- Moderate to severe malnutrition correlated with higher PSD incidence across all assessed indexes.
- PSD risk decreased over time, but malnutrition was linked to a slower decline in PSD risk.
- Body mass index (BMI) showed no significant association with PSD occurrence or development.
Conclusions:
- Malnutrition is a significant risk factor for developing PSD and influences its long-term trajectory.
- Nutritional status, particularly malnutrition, should be considered in managing PSD risk in stroke patients.
- BMI is not a significant predictor of PSD risk or its progression.
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