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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement

Barry A Borlaug1, Kavita Sharma2, Sanjiv J Shah3

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Journal of the American College of Cardiology
|May 3, 2023
PubMed

Insights

Heart failure with preserved ejection fraction (HFpEF) is increasingly common. Early recognition and tailored treatments are vital for improving outcomes in this complex condition.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Public Health

Background:

  • Heart failure with preserved ejection fraction (HFpEF) incidence and prevalence are rising due to aging, obesity, and cardiometabolic disorders.
  • Despite advances in understanding HFpEF pathophysiology and diagnosis, it remains under-recognized in clinical practice.
  • Effective treatments exist, highlighting the need for improved recognition and individualized care.

Purpose of the Study:

  • To provide an updated examination of HFpEF epidemiology, pathophysiology, diagnosis, and treatment.
  • To emphasize the importance of phenotyping for personalized HFpEF management.
  • To address the under-recognition of HFpEF in clinical practice.

Main Methods:

  • Review of current literature on HFpEF.
  • Analysis of epidemiological trends and risk factors.
  • Examination of pathophysiological mechanisms across cardiac, pulmonary, and extracardiac systems.
  • Evaluation of diagnostic strategies and treatment modalities.

Main Results:

  • HFpEF is a heterogeneous syndrome with increasing prevalence.
  • Under-recognition of HFpEF hinders timely and effective treatment.
  • Pathophysiological phenotyping is crucial for individualized treatment strategies.
  • Pharmacologic and lifestyle interventions show promise in improving HFpEF outcomes.

Conclusions:

  • HFpEF requires greater clinical attention due to its rising prevalence and significant morbidity.
  • Accurate diagnosis and phenotyping are essential for optimizing patient care.
  • Personalized treatment approaches, including pharmacologic and lifestyle interventions, can improve clinical status and reduce mortality in HFpEF.

Keywords:
diagnosisepidemiologyheart failure with preserved ejection fractionpathophysiologytreatment

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