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Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game

Nicholas M Provine1

  • 1Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Immunology and Cell Biology
|May 3, 2023
PubMed

In this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal co-administration of protein antigen with a strong MAIT cell ligand results in the the production of mucosal IgA and IgG antibody responses. This process is driven by MAIT cell-mediated maturation of migratory dendritic cells.

Keywords:
MAIT cellshumoral immunityvaccine adjuvant

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