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Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with
Luca Valore1, Till Junker1, Eva Heilmann2
1Hematology, University Hospital Basel, Basel, Switzerland.
Introduction:
Vaccine-induced myocarditis is a rare complication of messenger RNA (mRNA) COVID-19 vaccines.
Case Presentation:
We report a case of acute myopericarditis in a recipient of allogeneic hematopoietic cells following the first dose of the mRNA-1273 vaccine and the successful administration of a second and third dose while on prophylactic treatment with colchicine to successfully complete the vaccination.
Conclusion:
Treatment and prevention of mRNA-vaccine-induced myopericarditis represent a clinical challenge. The use of colchicine is feasible and safe to potentially reduce the risk of this rare but severe complication and allows re-exposure to an mRNA vaccine.
Insights
Messenger RNA (mRNA) COVID-19 vaccines can rarely cause myocarditis. Colchicine prophylaxis enabled a patient to safely complete vaccination after experiencing myopericarditis, demonstrating its potential use.
Area of Science:
- Immunology
- Cardiology
- Vaccinology
Background:
- Messenger RNA (mRNA) COVID-19 vaccines are associated with rare cases of myocarditis.
- Myocarditis following vaccination presents a clinical challenge, particularly in immunocompromised individuals.
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