Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

42.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.1K
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

4.4K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
4.4K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

108
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Expert Consensus on the Diagnosis and Clinical Management of Primary Fetal Pleural Effusion.

Prenatal diagnosis·2026
Same author

Linking maternal blood pressure with fetal cerebral haemodynamics and cortical growth in congenital heart disease.

EBioMedicine·2026
Same author

An MRI Atlas of the Human Fetal Brain: Reference and Segmentation Tools for Fetal Brain MRI Analysis.

Scientific data·2026
Same author

Role of Fetal Laryngoscopy in Prenatal Counseling for Fetuses With Congenital High Airway Obstruction Syndrome: A Case Report and Review of the Literature.

The journal of obstetrics and gynaecology research·2026
Same author

Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis.

Prenatal diagnosis·2026
Same author

Importance of placental evaluation in pregnancies at high risk for placenta accreta spectrum: Expert clinical perspective.

Pregnancy (Hoboken, N.J.)·2026

Related Experiment Video

Updated: Jul 31, 2025

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
04:25

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies

Published on: December 15, 2023

2.5K

Abnormal prenatal brain development in Chiari II malformation.

Olivia Masse1, Emily Kraft1, Esha Ahmad1

  • 1Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in Neuroanatomy
|May 4, 2023
PubMed
Summary

Chiari II malformation affects fetal brain development, causing smaller diencephalon volumes and larger ventricles. This highlights the need to consider regional brain changes in prenatal evaluations.

Keywords:
Chiari II malformationbirth defectsfetal brainfetusprenatal brain development

More Related Videos

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

921
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

20.7K

Related Experiment Videos

Last Updated: Jul 31, 2025

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
04:25

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies

Published on: December 15, 2023

2.5K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

921
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

20.7K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Chiari II malformation is a common birth defect linked to spinal abnormalities.
  • The exact pathophysiology and neurobiological basis of Chiari II beyond posterior fossa abnormalities are not fully understood.

Purpose of the Study:

  • To identify specific brain regions with altered development in fetuses diagnosed with Chiari II malformation.
  • To explore the neurobiological substrate of Chiari II in early fetal development.

Main Methods:

  • Utilized in vivo structural T2-weighted Magnetic Resonance Imaging (MRI) scans.
  • Analyzed data from 31 fetuses, including 6 healthy controls and 25 fetuses with Chiari II, between 17 and 26 gestational weeks (GW).

Main Results:

  • Fetuses with Chiari II exhibited significantly reduced diencephalon volumes compared to controls.
  • Enlarged lateral ventricles and proliferative zones (ventricular and subventricular zones) were observed in fetuses with Chiari II.

Conclusions:

  • Altered development in specific brain regions, including the diencephalon and proliferative zones, is associated with Chiari II malformation.
  • Prenatal assessment of Chiari II should incorporate evaluation of regional brain development patterns.