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Updated: Jul 31, 2025
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Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
Published on: August 23, 2018
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Risk Factors Associated with Bone Marrow Adiposity Deposition in Postmenopausal Women in the CASH China Study
Li Xu1, Yanping Gong2, Qian Zhao3
1Department of Radiology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
Summary
Bone marrow adipose tissue (BMAT) is influenced by age, estradiol/testosterone ratio, and TNF-α in postmenopausal women. Height and glucose levels also correlate with BMAT levels.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolic Health
Background:
- Bone marrow adipose tissue (BMAT) is an endocrine organ.
- Factors influencing BMAT are not fully understood, especially in postmenopausal women.
Purpose of the Study:
- To investigate factors influencing bone marrow adipose tissue (BMAT).
Main Methods:
- Quantitative computed tomography (QCT) and magnetic resonance imaging (MRI) were used to measure fat depots.
- Hormone, adipokine, and inflammatory factor levels were measured.
- Logistic regression analyses were performed on stratified data.
Main Results:
- Age, estradiol/testosterone ratio, and TNF-α independently affected BMAT.
- Height correlated with higher BMAT quartiles.
- Glucose levels correlated with lower BMAT quartiles.
Conclusions:
- BMAT is a unique fat depot influenced by age, sex hormones, and inflammation in postmenopausal women.
- Height and glucose are associated with BMAT levels.
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