Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benchmarking and fine-tuning vision-language models on a visual question answering dataset for myopic maculopathy.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2026
Same author

Sensory processing profiles and their association with tic severity in children with tic disorders: a cross-sectional study.

Child and adolescent psychiatry and mental health·2026
Same author

From prediction to action: developing a risk-stratified management tool for children with new-onset tic disorders.

Scientific reports·2026
Same author

Phase Boundary Engineering of Co<sub>2</sub>P-CoP Branched Nanoparticles Enhances Cobalt Oxidation for Oxygen Evolution Electrocatalysis.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A cross sectional study of optical coherence tomography angiography biomarkers and best corrected visual acuity in epiretinal membrane eyes.

International journal of retina and vitreous·2026
Same author

Efficacy, tolerability, and threshold effect of atropine eye drops for myopia control: A systematic review and dose-response meta-analysis.

Survey of ophthalmology·2026

Related Experiment Video

Updated: Jul 31, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.6K

Current microfluidic platforms for reverse engineering of cornea.

Qinyu Li1, Ho Lam Wong1, Yan Lam Ip1

  • 1Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, 999077, Hong Kong, China.

Materials Today. Bio
|May 4, 2023
PubMed
Summary
This summary is machine-generated.

Cornea-on-a-chip (CoC) platforms offer advanced in vitro models for studying corneal diseases and evaluating ophthalmic drugs, overcoming limitations of traditional animal testing. These microfluidic systems accelerate research and development for treating corneal blindness.

Keywords:
Cornea-on-a-chipCorneal microenvironmentMicrofluidic platformPharmacokineticsTissue engineering

More Related Videos

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

10.7K
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.2K

Related Experiment Videos

Last Updated: Jul 31, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.6K
Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

10.7K
Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.2K

Area of Science:

  • Ophthalmology
  • Biotechnology
  • Tissue Engineering

Background:

  • Corneal blindness affects 5.1% of the global population, with transplantation limited by donor tissue shortages.
  • Current animal models for ocular drug research face physiological and ethical limitations, hindering bench-to-bedside translation.
  • Novel ocular pharmaceutics are crucial for managing corneal disease progression.

Purpose of the Study:

  • To review engineered Cornea-on-a-chip (CoC) platforms as advanced in vitro models.
  • To highlight the merits, applications, and technical challenges of CoC technology.
  • To propose future directions for CoC development in corneal research.

Main Methods:

  • Integration of corneal cells with microfluidic systems to create CoC platforms.
  • Utilizing CoC to recapitulate the human corneal microenvironment.
  • Reviewing existing literature on CoC platform development and applications.

Main Results:

  • CoC platforms provide physiologically representative corneal models for studying disease and drug effects.
  • These models complement animal studies, enhancing the translatability of research findings.
  • CoC technology shows significant potential for preclinical screening of ophthalmic medications.

Conclusions:

  • Cornea-on-a-chip technology represents a significant advancement in in vitro corneal modeling.
  • CoC platforms can accelerate translational research and clinical treatment development for corneal diseases.
  • Further investigation into CoC technology is needed to address preclinical research obstacles.