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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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UK Reference Intervals for Parathyroid Hormone Using Abbott Methods.

Mehdi Mirzazadeh¹, Craig Webster², Gayani Weerasinghe³

¹Department of Chemical Pathology, Epsom and St Helier University Hospitals NHS Trust, Carshalton, United Kingdom.

British Journal of Biomedical Science

|May 4, 2023

Summary

This summary is machine-generated.

Accurate diagnosis of hyperparathyroidism needs local reference intervals for parathyroid hormone (PTH). Current manufacturer ranges may misclassify UK patients, necessitating revised upper thresholds for precise diagnosis.

Keywords:

age gender hyperparathyroidism parathyroid hormone reference intervals

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Published on: August 17, 2022

Area of Science:

Clinical Biochemistry
Endocrinology
Laboratory Medicine

Background:

Hyperparathyroidism diagnosis relies on parathyroid hormone (PTH) levels alongside calcium, vitamin D, and renal function.
Accurate patient classification necessitates appropriate population-specific reference intervals.
Existing reference intervals may not accurately reflect local populations.

Purpose of the Study:

To determine local population plasma PTH reference intervals at four UK sites.
To compare these intervals with manufacturer-provided ranges.
To assess the impact of local variations on hyperparathyroidism diagnosis.

Main Methods:

Plasma PTH results were collected from four UK laboratories using the Abbott Architect i2000 method.
Data included individuals with normal adjusted serum calcium, magnesium, vitamin D, and renal function.
Outlier rejection was performed before deriving reference limits using parametric and non-parametric approaches.

Main Results:

An overall UK reference interval of 3.0-13.7 pmol/L (non-parametric) was established, significantly higher than the manufacturer's 1.6-7.2 pmol/L range.
Statistically significant differences in upper limits (11.5-15.8 pmol/L) were observed between sites.
These variations suggest differences in local population characteristics.

Conclusions:

Locally derived reference intervals for plasma PTH are beneficial for UK populations.
Revised upper thresholds are needed for the Abbott PTH method to prevent misclassification of hyperparathyroidism.
Site-specific reference intervals may improve diagnostic accuracy.