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Biphasic drug release from electrospun structures.

Jianfeng Zhou1, Pu Wang1, Deng-Guang Yu1

  • 1School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.

Expert Opinion on Drug Delivery
|May 4, 2023
PubMed
Summary
This summary is machine-generated.

Electrospun nanofibers offer novel biphasic drug delivery systems (DDSs) by combining immediate and sustained release. Complex nanostructures from multi-fluid electrospinning are key to achieving this advanced drug release profile.

Keywords:
Biphasic releasedrug deliveryelectrospinningmechanismnanostructurespolymer

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Biphasic release combines immediate and sustained drug delivery for enhanced therapeutic action.
  • Electrospun nanofibers, especially complex nanostructures, show promise for novel biphasic drug delivery systems (DDSs).

Purpose of the Study:

  • To review recent advancements in electrospinning for creating nanostructures for biphasic drug release.
  • To explore the role and mechanisms of various electrospun nanostructures in achieving biphasic drug release.

Main Methods:

  • Review of literature on electrospinning techniques, including single-fluid, bifluid, and trifluid electrospinning.
  • Analysis of different electrospun nanostructures: monolithic, core-shell, Janus, three-compartment, nanofibrous assemblies, and combined mats with films.
  • Examination of strategies and mechanisms for biphasic release facilitated by these complex structures.

Main Results:

  • Monolithic, core-shell, Janus, and three-compartment nanofibers, along with nanofibrous assemblies and composite structures, were identified as effective for biphasic drug release.
  • Strategies for controlling drug release profiles through nanostructure design were analyzed.

Conclusions:

  • Electrospun nanostructures provide versatile strategies for developing biphasic drug release DDSs.
  • Challenges remain in scaling up production, in vivo validation, and integrating advanced electrospinning with pharmaceutical practices.