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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers
Zhi Xu1, Xin Li1, John A Rose1
1Department of Chemistry, Yale University, New Haven, Connecticut, 06520, USA. seth.herzon@yale.edu.
Abstract:
Covering: up to 2022Tricyclic bridgehead carbon centers (TBCCs) are a synthetically challenging substructure found in many complex natural products. Here we review the syntheses of ten representative families of TBCC-containing isolates, with the goal of outlining the strategies and tactics used to install these centers, including a discussion of the evolution of the successful synthetic design. We provide a summary of common strategies to inform future synthetic endeavors.
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