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Published on: November 5, 2021
An overview on COVID-19 and vaccines: findings and learnings from the pandemic
1Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, 11942, Saudi Arabia. abd.aldosari@psau.edu.sa.
Insights
This review details COVID-19
Area of Science:
- Hematology
- Virology
- Immunology
Background:
- The COVID-19 pandemic presents significant global health challenges.
- Ongoing debates surround public health measures like mask mandates and vaccine passports.
- Hematological complications are a notable aspect of COVID-19 disease.
Approach:
- A comprehensive literature review was performed.
- Keywords included "coronavirus disease", "COVID-19", "COVID-19 vaccinations", and "COVID-19 hematological complications".
- Analysis focused on mutations in non-structural proteins NSP2 and NSP3.
Key Points:
- COVID-19 is associated with various hematological issues, including coagulopathy and lymphopenia.
- Changes in platelet counts, blood cell levels, and hemoglobin are frequently observed.
- The review examines the impact of COVID-19 vaccination on hemolysis, multiple myeloma, and thrombocytopenia.
Conclusions:
- Understanding COVID-19's hematological effects is crucial for patient management.
- Vaccine development and their impact on hematological parameters require continued investigation.
- Prevention and symptom management remain key clinical challenges during the pandemic.
Abstract:
The coronavirus-2019 (COVID-19) pandemic continues to create global impact and continues to stand divided on the mask mandate, the vaccine passport, and the continuous testing process. The focus of this review is to highlight the hematological findings in COVID-19, complications, as well as impact of vaccinations. A detailed literature review has been conducted using keywords including "coronavirus disease", "COVID-19", "COVID-19 vaccinations", "COVID-19 hematological complications" to list a few. The findings highlight mutations in the non-structural proteins NSP2 and NSP3 to be crucial. With over fifty potential vaccine candidates in trial, prevention and symptom management continue to be the primary clinical challenge. Clinical studies have detailed the hematological complications of COVID-19, including coagulopathy, lymphopenia, and changes in levels of platelet, blood cells, and hemoglobin, to state a few. Further, we also discuss the impact of vaccination on hemolysis, on multiple myeloma patients, as well as thrombocytopenia.
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