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Updated: Jul 31, 2025

Intravitreous Injection for Establishing Ocular Diseases Model
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Intravitreal injections primary prevention: a case-control study.

F Avogaro1, A Florido, A Calandri

  • 1Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University, Rome, Italy. filippo.avogaro@uniroma1.it.

European Review for Medical and Pharmacological Sciences
|May 4, 2023
PubMed
Summary
This summary is machine-generated.

A new antiseptic drop, hexamidine diisethionate 0.05% (Keratosept), shows promising efficacy and better tolerability than povidone iodine for preventing endophthalmitis after intravitreal injections.

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Area of Science:

  • Ophthalmology
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Intravitreal injections (IVI) are common ophthalmology procedures.
  • Endophthalmitis is a feared complication of IVI.
  • Current prophylactic protocols for IVI are insufficient.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of hexamidine diisethionate 0.05% (Keratosept) as an antiseptic drop.
  • To compare Keratosept with povidone iodine 0.6% for prophylaxis during IVI.

Main Methods:

  • A single-center, case-control study.
  • Bacterial flora analyzed via conjunctival swabs before and after prophylaxis.
  • Patients received either Keratosept or povidone iodine for 3 days post-IVI.
  • Ocular tolerability assessed using an OSDi-based questionnaire.

Main Results:

  • Hexamidine diisethionate showed a reduction in positive conjunctival swabs post-treatment (9 vs 18).
  • Povidone iodine also showed a reduction (5 vs 13 positive swabs).
  • Higher patient numbers received Keratosept (55) versus povidone iodine (49) for tolerability assessment.

Conclusions:

  • Hexamidine diisethionate 0.05% (Keratosept) demonstrated good efficacy in reducing ocular bacterial flora.
  • Keratosept exhibited superior tolerability compared to povidone iodine 0.6% in the study sample.