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Effects of comorbidities associated with COVID-19 cases in Intensive Care Unit on mortality and disease progression

S Girgin1, M Aksun, A S Tüzen

  • 1Department of Anesthesiology and Reanimation, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. astuzen@icloud.com.

European Review for Medical and Pharmacological Sciences
|May 4, 2023
PubMed

Insights

Critical COVID-19 patients with hematologic malignancy or chronic renal failure face higher mortality. Advanced age and higher body mass index also correlate with poor survival in intensive care unit patients.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Oncology
  • Nephrology

Background:

  • The course and progression of COVID-19 are influenced by patient demographics and comorbidities.
  • Understanding factors affecting mortality in critically ill patients is crucial for effective treatment strategies.

Purpose of the Study:

  • To compare comorbidities associated with mortality in critically ill COVID-19 patients.
  • To assess the impact of comorbidities on survival rates in intensive care unit (ICU) patients with COVID-19.
  • To analyze comorbidities contributing to mortality in mechanically ventilated COVID-19 patients.

Main Methods:

  • Retrospective review of data from 408 COVID-19 patients admitted to the ICU with positive PCR tests.
  • Inclusion of a subgroup analysis for patients receiving invasive mechanical ventilation.
  • Statistical analysis to determine the significance of comorbidities and body mass index on mortality.

Main Results:

  • Patients with hematologic malignancy and chronic renal failure showed a statistically significant increase in mortality.
  • Higher body mass index was significantly associated with mortality in both the overall ICU cohort and the mechanically ventilated subgroup.
  • Advanced age was also identified as a factor linked to increased mortality.

Conclusions:

  • Underlying hematologic malignancy and chronic renal failure are significant risk factors for mortality in critically ill COVID-19 patients.
  • Advanced age, along with these specific comorbidities, contributes to a poor survival prognosis.
  • Elevated body mass index is a critical indicator associated with increased mortality in severe COVID-19 cases.
Abstract

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