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Updated: Jul 31, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Could treatment of autonomic dysfunction in early and prodromal Parkinson's disease slow disease progression?
1Department of Neurology, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States.
Abstract:
A recently published study by Ma et al. (Ma J, Dou K, Liu R, Liao Y, Yuan Z, Xie A. Front Aging Neurosci 14: 898149, 2022) investigated the 5-year longitudinal association between sleep disorders and depression in early and prodromal Parkinson's disease (PD). Not surprisingly, sleep disorders were associated with higher depression scores among patients with PD but, interestingly, autonomic dysfunction was revealed as a mediator between the two. This mini-review highlights these findings with an emphasis on the proposed benefit of autonomic dysfunction regulation and early intervention in prodromal PD.
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